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MK-677

Ibutamoren (INN) (developmental code names MK-677MK-0677L-163,191; former tentative brand name Oratrope) is a potent, long-acting, orally-activeselective, and non-peptide agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin.[3][4][5][6][7] It has been shown to increase the secretion of several hormones including GH and insulin-like growth factor 1 (IGF-1) and produces sustained increases in the plasma levels of these hormones without affecting cortisol levels.

 

Ibutamoren
Ibutamoren skeletal.svg
Clinical data
Synonyms MK-677; MK-0677; L-163,191; Oratrope
Routes of
administration
By mouth
Legal status
Legal status
Pharmacokinetic data
Elimination half-life 4–6 hours (in beagles);[1] IGF-1 levels remain elevated in humans with a single oral dose for up to 24 hours[2]
Identifiers
CAS Number
  •  159634-47-6
    159752-10-0 
PubChem CID
  •  
ChemSpider 154975
UNII
  •  
ECHA InfoCard  
Chemical and physical data
Formula C27H36N4O5S
Molar mass 528.662 g/mol

 

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