Meihua Biological Technology Co.,Ltd
 

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Lidocaine

 

Lidocaine

Lidocaine, also known as xylocaine and lignocaine, is a medication used to numb tissue in a specific area (local anesthetic).[4] It is also used to treat ventricular tachycardia and to perform nerve blocks.[3][4] Lidocaine mixed with a small amount of adrenaline (epinephrine) is available to allow larger doses for numbing, to decrease bleeding, and to make the numbing effect last longer.[4]When used as an injectable, it typically begins working within four minutes and lasts for half an hour to three hours.[4][5] Lidocaine mixtures may also be applied directly to the skin or mucous membranes to numb the area.

 

Lidocaine
Lidocaine.svg
Lidocaine-from-xtal-3D-balls.png
Clinical data
Pronunciation Lidocaine /ˈldəˌkn/[1][2]
lignocaine /ˈlɪɡnəˌkn/
Trade names Xylocaine, others
Synonyms N-(2,6-dimethylphenyl)-N2,N2-diethylglycinamide, lignocaine (AAN AU)
AHFS/Drugs.com

Local Monograph

Injectable Monograph
License data
  • EU EMA: by INN
Pregnancy
category
  • AU: A
  • US: B (No risk in non-human studies)
Routes of
administration
intravenoussubcutaneoustopicaloral
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • US: ℞-only (OTC for ≤4% for topical application for skin numbing use
or ≤5% for anorectal hemorroidal pain and to prevent premature ejaculation) Above 5% or other routes of administration: RX only.
Pharmacokinetic data
Bioavailability 35% (by mouth)
3% (topical)
Metabolism Liver,[3] 90% CYP3A4-mediated
Onset of action within 1.5 min (IV)[3]
Elimination half-life 1.5 h to 2 h
Duration of action 10 min to 20 min(IV),[3] 0.5 h to 3 h (local)[4][5]
Excretion Kidney[3]
Identifiers
CAS Number
  • 137-58-6
    73-78-9 (hydrochloride)
PubChem CID
  • 3676
IUPHAR/BPS 2623
  •  
DrugBank
  • DB00281
ChemSpider
  • 3548
UNII
  •  
KEGG
  •  
ChEBI  
ChEMBL
  •  
ECHA InfoCard  
Chemical and physical data
Formula C14H22N2O
Molar mass 234.34 g/mol

 

 

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