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Tetracaine hydrochloride
 
 
 
 
 

 

 

Tetracaine hydrochloride

CAS No.: 136-47-0
Synonyms:
Formula: C15H25ClN2O2
Exact Mass: 300.16000
Molecular Weight: 300.82400
PSA: 41.57000
LogP: 3.49200
Descriptiop
Tetracaine (also known as amethocaine) is a local anesthetic of the ester anesthetic group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
Tetracaine is the T in TAC, a mixture of 5 to 12 per cent tetracaine, 0.05 per cent adrenaline, and 4 or 10 per cent cocaine hydrochloride used in ear, nose & throat surgery and in the emergency department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
 
 
 
Properties
Appearance & Physical State: White or off white crystalline powder
Melting Point: 149ºC
Boiling Point: 389.4ºC at 760 mmHg
Flash Point: 189.3ºC
Stability: Stable at normal temperatures and pressures.
Storage Condition: Keep tightly closed.
Vapor Pressure: 2.87E-06mmHg at 25°C
 

 

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